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Overview
TB-500 is a synthetic peptide fragment associated with thymosin beta-4, a naturally occurring peptide involved in cell migration, tissue repair signaling, angiogenesis, and wound-healing pathways. It has been studied mainly through thymosin beta-4 research models, especially in tissue repair, inflammation, connective tissue remodeling, and vascular response.
Mechanism of Action
Research suggests TB-500/thymosin beta-4 may support repair-related pathways by binding actin, influencing cell migration, promoting angiogenesis, reducing inflammatory signaling, and supporting extracellular matrix remodeling during tissue recovery.
Compound Information
Stability Information
- Type: Synthetic thymosin beta-4 fragment
- Sequence: Ac-LKKTETQ
- Parent peptide: Thymosin beta-4
- Amino Acids: 7
- Category: Regenerative / tissue-repair research peptide
- Primary research areas: wound healing, angiogenesis, inflammation, connective tissue repair
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Thymosin beta4 accelerates wound healing.
- The actin binding site on thymosin beta4 promotes angiogenesis.
- Thymosin beta4 promotes angiogenesis, wound healing, and hair growth in normal and aged rodents.
- Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair.
- Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair.
- Thymosin beta4 promotes corneal wound healing and decreases inflammation in vivo.
- Thymosin beta4 enhances repair by organizing connective tissue and preventing myofibroblast appearance.
- Thymosin β4 administration enhances fracture healing in mice.
- Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and repair.
- Thymosin beta4 promotes matrix metalloproteinase expression during wound repair
- Thymosin beta4 improves dermal burn wound healing
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.