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Overview
Sermorelin is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH 1-29), representing the biologically active portion of endogenous GHRH. Research has focused on its ability to stimulate natural growth hormone secretion, increase IGF-1 production, and influence metabolic, endocrine, and tissue-repair pathways. Due to its short half-life and preservation of physiologic feedback mechanisms, Sermorelin has been extensively studied as a model GHRH analog.
Mechanism of Action
Research suggests Sermorelin binds to Growth Hormone-Releasing Hormone receptors (GHRH-R) on pituitary somatotroph cells, stimulating pulsatile release of endogenous growth hormone. Subsequent increases in circulating IGF-1 may influence protein synthesis, tissue growth, metabolism, and cellular repair pathways. Unlike exogenous growth hormone, Sermorelin relies on the body’s natural endocrine regulation mechanisms.
Compound Information
Stability Information
- Type: Growth Hormone-Releasing Hormone (GHRH) Analog
- Sequence: GHRH (1-29) NH₂
- Molecular Formula: C149H246N44O42S
- Amino Acids: 29
- Molecular Weight: 3357.9 g/mol
- Research Areas: Endocrinology, IGF-1 production, metabolism, growth hormone signaling
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Growth Hormone-Releasing Hormone and its analog Sermorelin in endocrine research.
- Effects of Sermorelin on growth hormone secretion in adults.
- Growth hormone-releasing hormone analogs and pituitary regulation.
- Sermorelin stimulates physiologic growth hormone release.
- Clinical pharmacology of GHRH (1-29) NH₂ analogs.
- Endocrine effects of growth hormone-releasing hormone administration.
- Regulation of IGF-1 production following GHRH stimulation.
- Growth hormone secretagogues and the somatotropic axis.
- Sermorelin and growth hormone physiology in research models.
- Growth hormone-releasing hormone analogs: mechanisms and applications.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.