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Overview
KPV (Lysine–Proline–Valine) is a naturally occurring tripeptide fragment derived from alpha-melanocyte-stimulating hormone (α-MSH). Research has focused on its anti-inflammatory properties, gastrointestinal health, immune modulation, skin barrier function, and inflammatory bowel disease models.
Mechanism of Action
Research suggests KPV may modulate inflammatory signaling pathways by reducing pro-inflammatory cytokine production, including TNF-α, IL-1β, and IL-6. Studies indicate it may influence innate immune responses and support epithelial barrier integrity in gastrointestinal and skin research models.
Compound Information
Stability Information
- Type: Synthetic tripeptide
- Sequence: Lys-Pro-Val (KPV)
- Parent Peptide: Alpha-Melanocyte-Stimulating Hormone (α-MSH)
- Amino Acids: 3
- Molecular Formula: C16H28N4O4
- Molecular Weight: 340.42 g/mol
- Research Areas: Gut health, inflammation, skin health, immune modulation
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Liposomal delivery of KPV peptide reduces colitis severity in experimental models.
- KPV exhibits anti-inflammatory activity independent of melanocortin receptors.
- KPV reduces cytokine production in inflammatory bowel disease models.
- Therapeutic potential of melanocortin peptides in inflammatory disorders.
- KPV attenuates experimental colitis through immune regulation
- Alpha-MSH peptides improve epithelial barrier function during inflammation.
- Melanocortin-derived peptides and gastrointestinal inflammation.
- KPV treatment decreases inflammatory signaling in epithelial cells.
- Anti-inflammatory effects of melanocortin peptides in mucosal disease.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.