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Overview
Nicotinamide Adenine Dinucleotide (NAD+) is a naturally occurring coenzyme found in all living cells and is essential for cellular energy production, mitochondrial function, DNA repair, and metabolic regulation. Research has focused on its role in redox reactions, cellular signaling, aging biology, mitochondrial health, neuroprotection, and metabolic homeostasis. NAD+ serves as a critical cofactor for enzymes such as sirtuins, PARPs, and CD38.
Mechanism of Action
Research suggests NAD+ functions as a central electron carrier in cellular metabolism, facilitating energy production through glycolysis, the citric acid cycle, and oxidative phosphorylation. Studies indicate NAD+ also serves as a substrate for sirtuins and PARP enzymes involved in DNA repair, gene regulation, stress responses, and mitochondrial signaling. Declining NAD+ levels have been associated with age-related metabolic dysfunction and impaired cellular resilience.
Compound Information
Stability Information
- Type: Endogenous Coenzyme
- Molecular Formula: C21H27N7O14P2
- Molecular Weight: 663.43 g/mol
- Molecular Weight: 663.43 g/mol
- Research Areas: Energy metabolism, mitochondrial function, aging, DNA repair
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- The NAD World: A New Systemic Regulatory Network for Metabolism and Aging.
- NAD+ Metabolism in Health and Disease.
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication During Aging.
- NAD+ Repletion Improves Mitochondrial and Stem Cell Function and Enhances Life Span in Mice.
- NAD+ and Mitochondrial Function in Aging and Disease.
- The Biology of NAD+ and Its Importance in Cellular Metabolism.
- NAD+ Precursors and Their Therapeutic Potential.
- Restoration of NAD+ Levels Improves Cellular Stress Resistance
- NAD+ Metabolism as a Target for Age-Associated Diseases.
- NAD+ Biology and Therapeutic Potential in Neurodegenerative Disorders.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.