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Overview
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4–7), modified with a Pro-Gly-Pro sequence to enhance stability. Research has focused on its effects on neuroprotection, cognitive function, neuroplasticity, neurotransmitter regulation, learning, memory, and recovery following neurological injury. Semax has been extensively investigated in neuroscience and neuroregeneration research.
Mechanism of Action
Research suggests Semax influences multiple neurobiological pathways, including modulation of BDNF (Brain-Derived Neurotrophic Factor), neurotransmitter signaling, neuroplasticity, and gene expression. Studies indicate it may affect dopaminergic, serotonergic, and neurotrophic systems while supporting neuronal adaptation and recovery processes. Increased BDNF expression has been observed following Semax administration in experimental models.
Compound Information
Stability Information
- Type: Synthetic Regulatory Peptide
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular Formula: C37H51N9O10S
- Amino Acids: 7
- Molecular Weight: 813.9 g/mol
- Research Areas: Cognition, neuroprotection, neuroplasticity, neuroscience
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- The peptide Semax affects expression of genes related to immune and vascular systems after cerebral ischemia.
- Semax binds specific sites in the basal forebrain and increases BDNF levels.
- Effects of Semax on the Default Mode Network of the Brain.
- Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax).
- Neuroprotective Peptides and New Strategies for Ischemic Stroke Treatment.
- The Potential of the Peptide Drug Semax and Its Derivative for Alzheimer's Research.
- Semax and PGP stimulate neuroglial and endothelial proliferation after ischemia.
- Semax affects amyloid-beta aggregation and copper-mediated neurotoxicity.
- Semax as a potential agent for ADHD and neurodevelopmental disorders.
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.