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Overview
Selank is a synthetic peptide derived from the endogenous immunomodulatory peptide tuftsin. Research has focused on its effects on neurotransmitter regulation, stress response, cognitive function, neuroplasticity, immune signaling, and behavioral neuroscience. Selank has been extensively investigated in preclinical and clinical research models involving anxiety-related behaviors, memory processes, and central nervous system function.
Mechanism of Action
Research suggests Selank modulates neurotransmitter systems including GABA, serotonin, dopamine, and norepinephrine pathways. Studies indicate it may influence the expression of brain-derived neurotrophic factor (BDNF), regulate inflammatory cytokines, and support neuroplasticity. Research has also examined its effects on stress adaptation and cognitive performance.
Compound Information
Stability Information
- Type: Synthetic Regulatory Peptide
- Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Parent Peptide: Tuftsin Analog
- Amino Acids: 7
- Molecular Formula: C33H57N11O9
- Molecular Weight: 751.9 g/mol
- Research Areas: Neuroscience, cognition, stress physiology, neuroplasticity
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Selank modulates expression of genes involved in neurotransmission and neuroplasticity.
- Effects of Selank on GABAergic neurotransmission in experimental models.
- Selank influences monoamine neurotransmitter systems in the brain.
- Neurochemical mechanisms underlying Selank activity.
- Effects of Selank on anxiety-related behavior and cognitive performance.
- Selank regulates cytokine production and immune system signaling.
- https://pubmed.ncbi.nlm.nih.gov/24225476/
- Comparative analysis of Selank and related regulatory peptides
- Peptide regulation of stress-response pathways in neuroscience research.
- https://pubmed.ncbi.nlm.nih.gov/31285702/
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.