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Overview
Melanotan II (MT-2) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide involved in melanocortin receptor signaling. Research has focused on pigmentation pathways, melanogenesis, UV protection mechanisms, appetite regulation, energy balance, and melanocortin receptor biology. MT-2 exhibits a longer half-life and greater receptor affinity than endogenous α-MSH.
Mechanism of Action
Research suggests Melanotan II acts as an agonist at multiple melanocortin receptors, particularly MC1R, MC3R, MC4R, and MC5R. Activation of MC1R stimulates melanogenesis and eumelanin production in melanocytes, while interactions with other melanocortin receptors have been investigated for their effects on appetite regulation, energy homeostasis, and endocrine signaling.
Compound Information
Stability Information
- Type: Synthetic Melanocortin Peptide
- Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Molecular Formula: C50H69N15O9
- Amino Acids: 7
- Molecular Weight: 1024.2 g/mol
- Research Areas: Pigmentation, melanogenesis, UV response, melanocortin signaling
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Melanotan-II induces skin pigmentation in humans through melanocortin receptor activation.
- Effects of Melanotan-II on human melanogenesis and pigmentation
- Melanocortin peptides and regulation of skin pigmentation
- Development of Melanotan-II as a potent melanocortin receptor agonist.
- Melanocortin receptor biology and synthetic peptide analogs.
- Melanocortin signaling pathways in pigmentation and photoprotection.
- Pharmacological characterization of Melanotan-II and melanocortin receptors.
- Role of melanocortin receptor agonists in UV-protective pigmentation responses.
- Melanocortin peptides regulate melanocyte function and eumelanin production.
- Synthetic melanocortin analogs and receptor-selective activity.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.