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Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring mitochondrial-derived peptide encoded within mitochondrial DNA. Research has focused on its role in metabolic regulation, cellular energy production, insulin sensitivity, exercise physiology, aging, and mitochondrial signaling. MOTS-c is recognized as one of several mitochondrial-derived peptides that may facilitate communication between mitochondria and the nucleus.
Mechanism of Action
Research suggests MOTS-c regulates metabolic homeostasis by influencing cellular energy sensing pathways, including AMPK activation and nuclear gene expression. Studies indicate it may enhance glucose utilization, support insulin sensitivity, regulate mitochondrial function, and promote adaptive responses to metabolic stress. Research has also explored its role in exercise performance and healthy aging.
Compound Information
Stability Information
- Type: Mitochondrial-Derived Peptide
- Full Name: Mitochondrial Open Reading Frame of the 12S rRNA-c
- Molecular Formula: C101H152N28O22S2
- Amino Acids: 16
- Molecular Weight: 2174.6 g/mol
- Research Areas: Metabolism, mitochondrial function, insulin sensitivity, aging
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Humanin and MOTS-c: mitochondrial-derived peptides in metabolic regulation.
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity.
- MOTS-c regulates nuclear gene expression to promote cellular adaptation to metabolic stress.
- MOTS-c improves insulin sensitivity and glucose metabolism in experimental models.
- Exercise-induced regulation of the mitochondrial peptide MOTS-c.
- MOTS-c as an exercise mimetic and regulator of physical performance.
- Mitochondrial-derived peptides and aging biology.
- MOTS-c promotes metabolic flexibility and adaptive stress responses.
- The role of mitochondrial peptides in age-related metabolic disease.
- MOTS-c and mitochondrial signaling pathways in health and disease.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.