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Overview
Ipamorelin is a synthetic pentapeptide classified as a growth hormone secretagogue. Research has focused on its selective stimulation of growth hormone release through activation of the ghrelin receptor (GHS-R1a). Unlike some earlier growth hormone secretagogues, Ipamorelin has demonstrated high selectivity for growth hormone release with minimal effects on cortisol and prolactin secretion in research models.
Mechanism of Action
Research suggests Ipamorelin binds to Growth Hormone Secretagogue Receptors (GHS-R1a) located primarily within the pituitary and hypothalamus. Activation of these receptors stimulates pulsatile growth hormone release while maintaining natural endocrine feedback mechanisms. Studies have investigated its effects on IGF-1 production, recovery pathways, body composition, muscle biology, and metabolic regulation.
Compound Information
Stability Information
- Type: Growth Hormone Secretagogue (GHS)
- Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Molecular Formula: C38H49N9O5
- Amino Acids: 5
- Molecular Weight: 711.85 g/mol
- Research Areas: Growth hormone release, IGF-1 production, metabolism, recovery
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Ipamorelin, a highly selective growth hormone secretagogue.
- Growth hormone-releasing properties of Ipamorelin in vitro and in vivo.
- Selective stimulation of growth hormone release by Ipamorelin.
- Pharmacological characterization of the growth hormone secretagogue Ipamorelin.
- Growth hormone secretagogues and endocrine regulation.
- Effects of Ipamorelin on growth hormone secretion in animal models.
- Ghrelin receptor activation and growth hormone release mechanisms.
- Growth hormone secretagogues: mechanism of action and therapeutic potential.
- Comparative analysis of synthetic growth hormone secretagogues.
- Selective GH release without significant cortisol or prolactin stimulation.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.