Tesamorelin Research

Overview

 

Tesamorelin is a synthetic growth hormone-releasing hormone analog studied for its effects on visceral adipose tissue, body composition, lipid metabolism, and liver fat in HIV-associated lipodystrophy and NAFLD research.

Mechanism of Action

Tesamorelin stimulates GHRH receptors in the pituitary, increasing endogenous growth hormone release and IGF-1 signaling. Research suggests this may promote lipolysis, reduce visceral fat, and influence hepatic fat metabolism

Compound Information

Stability Information

• Type: Synthetic GHRH analog
• CAS Number: 218949-48-5
• Molecular Formula: C221H366N72O67S
• Amino Acids: 44
• Category: Growth hormone-releasing hormone analog
• Research areas: visceral fat, lipodystrophy, liver fat, metabolic markers

• Room temperature stable (short-term)
• Protect from light
• Avoid repeated freeze-thaw cycles
• Lyophilized: Store at -20°C
• Reconstituted: Store at 2-8°C

Published Studies

• Metabolic effects of a growth hormone-releasing factor in HIV patients.
• Effects of tesamorelin in HIV-infected patients with abdominal fat accumulation.
• Pooled phase-3 analysis of tesamorelin in ART-treated HIV patients.
• Long-term safety and effects of tesamorelin.
• Placebo-controlled dose-ranging study of growth hormone-releasing factor.
• Tesamorelin review for HIV-associated lipodystrophy.
• Effect of tesamorelin on visceral fat and liver fat.
• Reduction in visceral adiposity and metabolic markers.
• Effects of tesamorelin on NAFLD in HIV.
• Effects of tesamorelin on hepatic transcriptomic signatures

Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.