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Overview
5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small-molecule compound investigated for its effects on cellular metabolism and fat metabolism pathways. Research has focused on its ability to inhibit Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in energy regulation, adipogenesis, and metabolic function. Studies have explored its potential role in body composition, energy expenditure, and metabolic health.
Mechanism of Action
Research suggests 5-Amino-1MQ functions as an NNMT inhibitor. By reducing NNMT activity, it may increase intracellular nicotinamide availability and influence NAD+ metabolism, cellular energy production, and adipocyte function. Preclinical studies indicate NNMT inhibition may support increased energy expenditure and reduced fat accumulation.
Compound Information
Stability Information
- Type: Small Molecule NNMT Inhibitor
- Chemical Name: 5-Amino-1-Methylquinolinium
- Molecular Formula: C10H11N2+
- Molecular Weight: 159.21 g/mol
- Target: Nicotinamide N-Methyltransferase (NNMT)
- Research Areas: Metabolism, adiposity, energy expenditure, NAD+ pathways
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Nicotinamide N-methyltransferase is a regulator of obesity and energy metabolism.
- NNMT inhibition increases cellular metabolic activity and reduces adiposity.
- Small molecule inhibitors of NNMT for metabolic disease research.
- Discovery and characterization of potent NNMT inhibitors.
- NNMT regulates hepatic nutrient metabolism through SIRT1 stabilization.
- Targeting NNMT as a therapeutic strategy for metabolic disorders.
- Role of NNMT in obesity and adipose tissue metabolism.
- Nicotinamide metabolism and energy homeostasis.
- Pharmacological inhibition of NNMT improves metabolic parameters in preclinical models.
- NNMT as a central regulator of metabolic disease and energy expenditure.
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.