Overview
CJC-1295 No DAC is a synthetic Growth Hormone Releasing Hormone (GHRH) analog designed to stimulate the natural release of growth hormone from the pituitary gland. Unlike the DAC-modified version, CJC-1295 No DAC has a significantly shorter half-life, making it useful for studies examining pulsatile growth hormone secretion, IGF-1 production, recovery processes, body composition, and endocrine regulation.
Mechanism of Action
Research suggests CJC-1295 No DAC binds to GHRH receptors in the anterior pituitary, stimulating endogenous growth hormone release. This may subsequently increase circulating IGF-1 levels while preserving normal physiologic hormone feedback mechanisms. Studies have investigated its effects on growth hormone pulsatility, protein synthesis, tissue repair signaling, and metabolic regulation.
Compound Information
Stability Information
- Type: Synthetic GHRH Analog
- Sequence: Modified GRF (1-29)
- Amino Acids: 29
- Molecular Formula: C152H252N44O42
- Molecular Weight: 3367.9 g/mol
- Research Areas: Growth hormone release, IGF-1 production, recovery, body composition
- Room temperature stable (short-term)
- Protect from light
- Avoid repeated freeze-thaw cycles
- Lyophilized: Store at -20°C
- Reconstituted: Store at 2-8°C
Published Studies
- Prolonged stimulation of growth hormone and IGF-1 secretion by CJC-1295
- Enhanced pulsatile growth hormone secretion after GHRH analog administration.
- Growth hormone-releasing hormone and regulation of the somatotropic axis.
- Clinical pharmacology of CJC-1295 in healthy adults
- Effects of GHRH analogs on IGF-1 secretion and endocrine regulation.
- Growth hormone secretagogues and their physiological actions.
- Role of GHRH analogs in modulation of body composition and metabolism
- Growth hormone pulse amplification through GHRH receptor activation.
- Pharmacokinetic and pharmacodynamic properties of modified GRF peptides.
- Endocrine effects of synthetic GHRH analogs in human research models
Information provided for educational and research reference purposes only. Studies listed are third-party publications and do not constitute medical advice.